Grow Youthful: How to Slow Your Aging and Enjoy Extraordinary Health
Grow Youthful: How to Slow Your Aging and Enjoy Extraordinary Health

Benign prostatic hyperplasia / hypertrophy (BPH)

What is BPH?

Symptoms of BPH

BPH and cancer

BPH causes and risk factors

Prevention / remedies / cures / treatment for BPH

References

What is BPH?

Enlargement of the prostate gland (benign prostatic hyperplasia, benign prostatic hypertrophy or BPH) is a common problem in middle-aged and older men. The urethra is choked by an enlarged prostate gland.

BPH almost always involves hyperplasia (an increase in the number of cells) rather than hypertrophy (a growth in the size of the individual cells).

BPH rarely occurs in men under the age of 40. There is evidence of BPH in 40% of men in their 50's, nearly 70% in their 60's, and up to 90% in their seventies and eighties. In nearly half these cases, the symptoms are severe enough to need treatment. The degree of severity ranges from being a nuisance to requiring major accommodations to a person's lifestyle. The most serious situation is an inability to urinate, which may need hospitalisation and bladder catheterization. BPH is not normally painful.

Interestingly, in most men oestradiol levels start climbing from the age of fifty and peak in their late 60's. During the same period progesterone levels decline, just the opposite to oestradiol.

Symptoms of BPH

BPH and cancer

Elevated and rising levels of prostate specific antigen (PSA) have a high correlation with prostate cancer. However, there is disagreement on whether BPH can lead to prostate cancer, which is one of the most common forms of cancer in men.

High levels of the female estrogen hormones and chemicals that mimic estrogen exist in our environment today. Studies show that when prostate cells are exposed to excessive estrogen, they proliferate and eventually become cancerous. Having sufficient progesterone protects against this effect, and to a lesser extent testosterone also protects. Unfortunately, as men age their levels of both progesterone and testosterone fall. This is why BPH is so common in older men, and almost unheard of in young men. As you would expect, when the low level of progesterone (and testosterone) is corrected, the BPH cellular growth (the enlargement or swelling) and even cancers are reversed.

BPH causes and risk factors

Prevention / remedies / cures / treatment for BPH

Estrogen and insulin are two hormones associated with growth. Dairy products contain various forms of estrogen which make a calf grow quickly. Do everything possible to minimise estrogen and insulin to avoid unwanted growth of the prostate.

References

1. Buck A.C., et al. Treatment Of Outflow Tract Obstruction Due To Benign Prostatic Hyperplasia With The Pollen Extract Cernilton, A Double-Blind, Placebo-Controlled Study. British Journal of Urology 66:398-404. 1990.

2. Professor Graham Giles. Cancer Council, Victoria, Australia. British Journal of Urology, July 2003.

3. T. Colin Campbell. The China Study. Startling Implications for Diet, Weight Loss and Long-Term Health. BenBella Books, 2006.

4. Lloyd JC et al. Effect of isocaloric low fat diet on prostate cancer xenograft progression in a hormone deprivation model. Journal of Urology 2010 Apr;183(4):1619-24.

5. Helene Rundqvist, Martin Augsten, Anna Stromberg, Eric Rullman, Sara Mijwel, Pedram Kharaziha, Theocharis Panaretakis, Thomas Gustafsson, Arne Ostman. Effect of Acute Exercise on Prostate Cancer Cell Growth. PLoS ONE 8(7): e67579. doi:10.1371/journal.pone.0067579. Published 5 July 2013.

6. Line Pedersen, Manja Idorn, Gitte H. Olofsson, Britt Lauenborg, Intawat Nookaew, Rasmus Hvass Hansen, Helle Hjorth Johannesen, Jurgen C. Becker, Katrine S. Pedersen, Christine Dethlefsen, Jens Nielsen, Julie Gehl, Bente K. Pedersen, Per thor Straten, Pernille Hojman. Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. Cell Metabolism, Volume 23, Issue 3, p554-562, 8 March 2016.

7. Ornish D, Weidner G, Fair WR, Marlin R, Pettengill EB, Raisin CJ, Dunn-Emke S, Crutchfield L, Jacobs FN, Barnard RJ, Aronson WJ, McCormac P, McKnight DJ, Fein JD, Dnistrian AM, Weinstein J, Ngo TH, Mendell NR, Carroll PR. Intensive lifestyle changes may affect the progression of prostate cancer. Journal of Urology. September 2005. 174(3):1065-9; discussion 1069-70.

8. Dean Ornish, Mark Jesus M. Magbanua, Gerdi Weidner, Vivian Weinberg, Colleen Kemp, Christopher Green, Michael D. Mattie, Ruth Marlin, Jeff Simko, Katsuto Shinohara, Christopher M. Haqq, Peter R. Carroll. Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Proceedings of the National Academy of Sciences. 17 June 2008. 105(24): 8369-8374. Published online 2008 Jun 16. doi: 10.1073/pnas.0803080105. PMCID: PMC2430265.

9. R James Barnard, Tung H Ngo, Pak-Shan Leung, William J Aronson, Lawrence A Golding. A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro. Prostate. 2003 Aug 1;56(3):201-6. PMID: 12772189.

10. R J Barnard, N Kobayashi, W J Aronson. A low-fat, low-fiber diet and daily exercise lowers insulin and reduces growth of prostate cells. Prostate Cancer Prostatic Dis. 2008;11(4):362-6. Epub 2008 Feb 19. PMID: 18283296.

11. Trude Eid Robsahm, Steinar Tretli, Arne Dahlback, Johan Moan. Vitamin D3 from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway). Cancer Causes & Control. March 2004, Volume 15, Issue 2, pp 149-158.

12. Benjamin N Breyer 1, Aruna V Sarma. Hyperglycemia and insulin resistance and the risk of BPH/LUTS: an update of recent literature. Curr Urol Rep. 2014 Dec; 15(12): 462. doi: 10.1007/s11934-014-0462-x

13. Wolfgang Kopp. Diet-Induced Hyperinsulinemia as a Key Factor in the Etiology of Both Benign Prostatic Hyperplasia and Essential Hypertension? Nutr Metab Insights. 2018 May 8;11:1178638818773072. doi: 10.1177/1178638818773072. eCollection 2018.