Grow Youthful: How to Slow Your Aging and Enjoy Extraordinary Health
Grow Youthful: How to Slow Your Aging and Enjoy Extraordinary Health

Cancer

What is cancer?

The six (now seven) hallmarks of cancer

Symptoms of cancer

Cancer is a disease of energy metabolism

Causes of cancer

Mitochondria

Causes of damage to mitochondria

Why oncologists don't get it, and don't want to get it

3BP is an effective treatment using the energy model

Cancer remedies / treatments

References

What is cancer?

Conventional doctors and standard medicine describe cancer (medical description is malignant neoplasm) as a broad group of over 200 diseases in which cell growth and communication gets out of control. A cancerous group of cells divide and grow abnormally. They can form malignant tumours, invade and destroy adjacent tissue, or metastasise (spread to other locations throughout the body via lymph or blood). Most cancers form a tumour, but some such as leukaemia do not.

Not all tumours are cancerous. Benign tumours do not grow uncontrollably, do not invade neighbouring tissues, and do not metastasise.

The standard medical treatment for cancer is a combination of one or more of chemotherapy, radiation therapy or surgery. When using these treatments, the survival rate depends upon the type and location of the cancer, the health of the patient, and the extent of disease at the start of treatment.

The risk of cancer increases with age, and the majority of people who are diagnosed with an invasive cancer are over the age of 65. The most common types of cancer in children are leukaemia, brain tumours, lymphomas and blastomas. According to the WHO, cancer caused about 17% of all human deaths worldwide in 2016, up from 13% in 2007. The most common forms are lung, stomach, liver, colorectal and breast cancer. Cancer is the leading cause of death in the developed countries, and the second most common cause in developing countries.

Rates are rising as more people live to an older age and live a more cancer-prone lifestyle.

The six (now seven) hallmarks of cancer

  1. Cancer cells stimulate their own growth.
  2. Resist growth-suppressing signals.
  3. Resist apoptosis (cell death).
  4. Are able to multiply indefinitely.
  5. Can grow new blood vessels for tumour growth.
  6. Spread to other parts of the body (metastasis).
  7. In 2010 Weinberg (18) updated his list by suggesting that there was a seventh hallmark, "reprogramming of energy metabolism". This is an important characteristic of cancer. However, he did not go as far as explaining how or why this reprogramming occurs.

Symptoms of cancer

When a cancer starts, it produces no symptoms. Signs and symptoms only appear as it grows, progresses or ulcerates. At first, the symptoms may be mild, non-specific, and similar to the symptoms that occur with a variety of other conditions. It is not uncommon for early-stage patients to be treated for other ailments that cause the same symptoms.

The local symptoms of a cancer are caused by the mass of a tumour, or its ulceration. Blockages, lumps, swelling, bleeding or the build-up of fluid in the chest or abdomen can occur. Initially cancers are usually painless, and pain occurs only in advanced stages.

The systemic or generalised symptoms of cancer are weight loss, fever, being excessively tired, and changes to the skin. Other more specific symptoms for some types of cancers may include clubbing of the fingers and nails, and nerve disorders.

When metastasis occurs, the lymph nodes, liver or spleen can swell, affected bones may fracture, and neurological symptoms can occur.

Cancer is a disease of energy metabolism

All life, whether we are talking about plants, animals, germs or the modern-day economy, is dependent on energy. Otto Warburg was well aware of this, and in 1906 decided to investigate how cancer cells obtained and used their energy.

The fact that cancer is a hotchpotch of different growths, affecting different organs and tissues, convinced Warburg that cancer was a problem of energy metabolism. Nothing else would explain the myriad of different ways that cancer manifests.

All animal cells are powered by aerobic respiration, which is the production of energy using oxygen. If there is insufficient oxygen, such as when swimming under water, sprinting flat out, or lifting weights to the max, then energy is created anaerobically. Anaerobic energy always produces lactic acid, and in 1924 Warburg showed that cancer cells produce lactic acid. The process by which cancer cells ferment glucose rather than burning it with oxygen is known as the Warburg effect. The Warburg effect occurs in all cancer cells without exception. (19, 21, 34)

Warburg concluded that cancer is caused by a permanent alteration to the respiration mechanism in a cell. This alteration involves damaging of the cell's mitochondria, so that it no longer produces sufficient ATP (the normal energy molecule). To compensate for the lack of ATP, cancer cells generate energy by fermenting glucose. Fermentation is done without oxygen, in fact oxygen stops the fermentation process. (19, 34)

Research as early as 1987 proved that cancer has metabolic and not genetic origins. (22) This was confirmed by work at the University of Vermont done by Warren Schaeffer. It was all ignored by the National Cancer Institute.

"When cancer is framed as a metabolic disease, the entire paradigm of treatment is turned inside out. Doctors are treating a single disease, and they are treating "sick" cells, not the immortal supper cells that genetic theory paints them as." (27, 34, 35)

Causes of cancer

Damaged mitochondria. Mitochondria are the energy generators in every cell. They take the glucose in the blood and convert it into ATP, the energy molecule. When mitochondria are damaged, cells revert to fermenting glucose to get their energy. Cancer rapidly appears in this environment. Mitochondria are discussed below, along with a list of causes of damage.

Continual eating. The average American has seventeen "eating events" per day. Their blood glucose is continually elevated, and insulin and other hormones are kept at artificially high (or low) levels all day. A nonstop diet high in sugar, refined and processed foods is almost certainly the major cause of cancer. Cancer cells are highly dependent on glucose, and die if they have to use ketones or fats for energy.

Lack of physical activity. The modern lifestyle involves long periods of sitting and inactivity. Exercise need not be strenuous, but the human body needs to walk and move for several hours every day. Inactivity is deadly.

Lack of oxygen. At sea level, pristine air comprises 20% oxygen. In urban areas, where vehicles, heaters, power stations and other exhausts spew carbon dioxide and other gases into the atmosphere, the oxygen level falls to around 10%. When combined with low levels of physical activity, most people simply do not get enough oxygen.

Negative attitude, lack of gratefulness, powerlessness, isolation, blockages. (31, 37, 38)

Mitochondria

Early in the development of life upon the earth, mitochondria existed as separate, independent bacteria. Through a twist of fate, one of these bacteria found its way into another cell, where it continued to live. When this cell reproduced, it reproduced with the mitochondrial bacterium included. This relationship proved advantageous for both the mitochondria and the host cell. The mitochondria specialised in producing energy, and the host cell specialised in all the other aspects of cellular health and reproduction.

Mitochondria got so good at manufacturing ATP (adenosine triphosphate, the cell's energy molecule) that they were incorporated to power every animal. At any time, an adult human has about 250 grams (9oz) of ATP stored in its cells. What is amazing is how rapidly this ATP is produced and used - every day a human produces and uses their body weight in ATP.

The production of ATP requires oxygen and produces free radicals. To neutralise these damaging free radicals, mitochondria produce antioxidants uric acid, glutathione, lipoic acid, vitamins C and E, and antioxidant enzymes.

It follows that damaged or aged mitochondria do not produce sufficient energy, and do not fully neutralise free radicals. Both toxins and viruses can damage a cell's mitochondria.

Causes of damage to mitochondria

Why oncologists don't get it, and don't want to get it

In 1971 US president Nixon declared war on cancer. With taxpayer support and a massive budget, Americans believed it would take only a few years to find a general cure for cancer. Nearly half a century later, cancer is the second biggest cause of death in America and could soon be the first. What went wrong?

Under the Western medical system, and particularly in the USA, cancer is an extraordinarily profitable disease to treat. In the USA in 2017, a course of radiation therapy cost $7,500-$26,000. Chemotherapy can cost between $5,000 and $30,000 per month. Newly approved cancer drugs cost between $10,000 and $30,000 per month. Doctors and oncologists get a percentage of the drugs and treatments that they recommend.

Pharmaceutical companies, with their immense wealth and lobbying power, now control their own regulators, all medical regulators and associations, university teaching and curricula, and the funds for most cancer research.

At present the majority view is that cancer is a genetic disease. This is what doctors are taught, this is how current medical treatments are oriented, and this is what pharmaceutical companies want us to believe. If researchers can identify the specific genes that cause each type of cancer, then it becomes possible to develop patented pharmaceutical and genetic treatments. This is the Holy Grail of cancer research, because patented products that patients and their loved ones believe can save their life are so profitable. Witness a number of new drugs in 2017 priced at over $100,000 per patient per year.

Unfortunately for the various cancer industries, the explanation that cancer is a genetic disease does not stack up. Cancers are a hotchpotch of different growths that seem impossible to tie down to specific genes. The failure of the immune system to destroy the first few cancer cells, the mechanism by which they take hold and grow, and the way they move to other parts of the body (metastasis), does not make sense from a genetic point of view.

3BP is an effective treatment using the energy model

In the late 1990s a molecular biologist Young Hee Ko realised that all cancer cells needed a way to get rid of the large quantities of lactic acid they were producing while fermenting glucose. She surmised that a molecule by the name of 3-bromopyruvate had a structure similar to lactic acid and may be able to enter cancer cells with ease. In her laboratory she confirmed that 3BP did indeed effortlessly enter cancer cells, and it killed cancer cells vastly more effectively than any other known cancer drug or molecule. 3BP worked with every type of cancer she tested: brain, breast, colon, kidney, liver, lung, ovarian, pancreatic, prostate and skin. Her tests also showed that 3BP attacked only cancer cells, and left other cells intact.

Starting in 2002, as Ko tried to move her research forward and eventually into human trials, she suffered a series of political, administrative and legal attacks that resulted in her termination as a cancer researcher and the effective loss of her 3BP patents.

In the Netherlands in 2009 the first human trial of 3BP finally confirmed its total effectiveness. Ko's patented formulation was injected by a specialist into the liver of a near-terminal liver cancer patient. Eight months later, the only signs of cancer around his body were the remains of the now-dead tumours. (20) However, funding problems and lawsuits continued to hold up further trials.

A number of alternative cancer clinics started using 3BP for cancer treatment. However, the suspicious deaths of several people who were treated with 3BP at a cancer centre in Germany has put even the unapproved use of 3BP on hold. These people were terminal cases who had no other treatment options available. German authorities have reason to believe that the patients at this clinic died under suspicious circumstances, and the investigation is still under way.

3BP is a cheap cancer therapy. The cost of the 3BP itself for a full treatment is around $100. (27)

Cancer remedies / treatments

The most effective treatments for cancer, namely ketogenic diet and oxygen, are not being widely researched because they are too cheap and simple. There is no possibility that the pharmaceutical industry can make money from the use of ketogenic dieting. If everybody started eating less, and eating only one large meal each day, cancer would largely disappear from the planet. But this is not going to happen either - the giant food industries are pressing food upon their consumers until food is literally raining down upon people all day and all night too. According to Veech, (25, 26) "ketosis is the normal physiological state. It is not normal to have a McDonalds on every corner. It is normal to starve."

References

1. Sasco AJ, Secretan MB, Straif K. Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer. 2004 Aug;45 Suppl 2:S3-9.

2. Biesalski HK, Bueno de Mesquita B, Chesson A, Chytil F, Grimble R, Hermus RJ, Kohrle J, Lotan R, Norpoth K, Pastorino U, Thurnham D. European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel. CA Cancer J Clin. 1998 May-Jun;48(3):167-76; discussion 164-6.

3. Schutze M. et al. Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ. 2011 Apr 7;342:d1584. doi: 10.1136/bmj.d1584.

4. Irigaray P, Newby JA, Clapp R, Hardell L, Howard V, Montagnier L, Epstein S, Belpomme D. Lifestyle-related factors and environmental agents causing cancer: an overview. Biomed Pharmacother. 2007 Dec;61(10):640-58. Epub 2007 Nov 20.

5. WHO calls for prevention of cancer through healthy workplaces. World Health Organisation, 27 April 2007.

6. Little J.B. Chapter 14: Ionizing Radiation. In Kufe D.W., Pollock R.E., Weichselbaum R.R., Bast R.C. Jr, Gansler T.S., Holland J.F., Frei E. III. Cancer medicine. 2000. Hamilton, Ont: B.C. Decker. ISBN 1-55009-113-1.

7. Rivera CA et al. Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. BMC Gasttoenterol. 2010 May 28; 10(1):52.

8. LLoyd JC et al. Effect of Isocaloric Low Fat Diet on Prostrate Cancer Xenograft Progression in a Hormone Deprivation Model. J Urol. 2010 April; 183(4):1619-24.

9. Le TT et al. Coherent anti-Stokes Raman scattering imaging of lipids in cancer metastasis. BMC Cancer. 2009 Jan 30; 9:42.

10. Veronica Estrella, Tingan Chen, Mark Lloyd, Jonathan Wojtkowiak, Heather H Cornnell, Arig Ibrahim-Hashim, Kate Bailey, Yoganand Balagurunathan, Jennifer M Rothberg, Bonnie F Sloane, Joseph Johnson, Robert A Gatenby, Robert J. Gillies. Acidity generated by the tumor microenvironment drives local invasion. Cancer Research. Published Online 1 January 2013, doi: 10.1158/0008-5472.

11. Kirsten C.G. Van Dycke, Wendy Rodenburg, Conny T.M. van Oostrom, Linda W.M. van Kerkhof, Jeroen L.A. Pennings, Till Roenneberg, Harry van Steeg, Gijsbertus T.J. van der Horst. Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice. Current Biology, 20 July 2015, Volume 25, Issue 14, 1932-1937.

12. Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK. Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. BMC Complement Altern Med. 2011 Dec 15;11:129. doi: 10.1186/1472-6882-11-129.

13. Anasuya Ray, Smreti Vasudevan, Suparna Sengupta. 6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death. PLOS One. DOI: 10.1371/journal.pone.0137614. 10 September 2015.

14. Miho Akimoto, Mari Iizuka, Rie Kanematsu, Masato Yoshida, Keizo Takenaga. Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death. PLOS One. 11 May 2015. DOI: 10.1371/journal.pone.0126605.

15. Yan Ma, Julia Chapman, Mark Levine, Kishore Polireddy, Jeanne Drisko,Qi Chen. High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy. Science Translational Medicine 05 Feb 2014: Vol. 6, Issue 222, pp. 222ra18, DOI: 10.1126/scitranslmed.3007154.

16. Helene Rundqvist, Martin Augsten, Anna Stromberg, Eric Rullman, Sara Mijwel, Pedram Kharaziha, Theocharis Panaretakis, Thomas Gustafsson, Arne Ostman. Effect of Acute Exercise on Prostate Cancer Cell Growth. PLoS ONE 8(7): e67579. doi:10.1371/journal.pone.0067579. Published 5 July 2013.

17. Line Pedersen, Manja Idorn, Gitte H. Olofsson, Britt Lauenborg, Intawat Nookaew, Rasmus Hvass Hansen, Helle Hjorth Johannesen, Jurgen C. Becker, Katrine S. Pedersen, Christine Dethlefsen, Jens Nielsen, Julie Gehl, Bente K. Pedersen, Per thor Straten, Pernille Hojman. Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. Cell Metabolism, Volume 23, Issue 3, p554-562, 8 March 2016.

18. Hanahan D, Weinberg RA. The Hallmarks of Cancer. January 2000, Cell. 100 (1): 57-70. PMID 10647931. doi:10.1016/S0092-8674(00)81683-9.

19. Peter L Pedersen. Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J Bioenerg Biomembr. 2007 Jun;39(3):211-22.

20. Ko YH, Verhoeven HA, Lee MJ, Corbin DJ, Vogl TJ, Pedersen PL. A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside. J Bioenerg Biomembr. 2012 Feb;44(1):163-70. doi: 10.1007/s10863-012-9417-4. Epub 2012 Feb 11.

21. Thomas N. Seyfried, Roberto E. Flores, Angela M. Poff, Dominic P. D'Agostino. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014 Mar; 35(3): 515-527. Published online 16 December 2013. doi: 10.1093/carcin/bgt480. PMCID: PMC3941741.

22. Shay Jerry W, Werbin H. Cytoplasmic suppression of tumorigenicity in reconstructed mouse cells. Cancer Res. 1988 Feb 15;48(4):830-3. PMID: 3123054.

23. Watson J. Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol. 2013 Jan 8;3(1):120144. doi: 10.1098/rsob.120144.

24. Angela M. Poff, Csilla Ari, Thomas N. Seyfried, Dominic P. D'Agostino. The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer. PLoS One. 2013; 8(6): e65522. Published online 5 June 2013. doi: 10.1371/journal.pone.0065522. PMCID: PMC3673985.

25. Veech RL. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):309-19.

26. Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF Jr. Ketone bodies, potential therapeutic uses. IUBMB Life. 2001 Apr;51(4):241-7.

27. Travis Christofferson. Tripping Over the Truth: How the metabolic theory of cancer is overturning one of medicine's most entrenched paradigms. Chelsea Green Publishing 2017. ISBN 978-1-60358-729-7.
This book provides a good description of the strict ketogenic diet and how to implement it.

28. charliefoundation.org explains ketogenic diets and provides food details.

29. V. Gopalakrishnan, C. N. Spencer, L. Nezi, A. Reuben, M. C. Andrews, T. V. Karpinets, P. A. Prieto, D. Vicente, Jennifer A. Wargo. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 02 Nov 2017: eaan4236. DOI: 10.1126/science.aan4236.

30. Noelle K. LoConte, Abenaa M. Brewster, Judith S. Kaur, Janette K. Merrill, and Anthony J. Alberg. Alcohol and Cancer: A Statement of the American Society of Clinical Oncology. DOI: 10.1200/JCO.2017.76.1155 Journal of Clinical Oncology - published online before print 7 November 2017. PMID: 29112463.

31. Kelly A. Turner. Radical Remission. Surviving cancer against all the odds. The nine key factors that can make a real difference. Harper Collins, 2014.

32. Dunaif GE, Campbell TC. Relative contribution of dietary protein level and aflatoxin B1 dose in generation of presumptive preneoplastic foci in rat liver. Journal of the National Cancer Inst. February 1987;78(2):365-9.

33. Youngman LD, Campbell TC. Inhibition of aflatoxin B1-induced gamma-glutamyltranspeptidase positive (GGT+) hepatic preneoplastic foci and tumors by low protein diets: evidence that altered GGT+ foci indicate neoplastic potential. Carcinogenesis. 1992 Sep;13(9):1607-13.

34. Ponisovskiy MR. Warburg effect mechanism as the target for theoretical substantiation of a new potential cancer treatment. Critical Reviews in Eukaryotic Gene Expression. 2011;21(1):13-28.

35. Yu, M. Somatic mitochondrial DNA mutations in human cancers. Advances in Clinical Chemistry. 2012; 57:99-138.

36. McGregor BA, Antoni MH, Boyers A, Alferi SM, Blomberg BB, Carver CS. Cognitive-behavioral stress management increases benefit finding and immune function among women with early-stage breast cancer. Journal of Psychosomatic Research. January 2004. 56(1):1-8.

37. Chou AF, Stewart SL, Wild RC, Bloom JR. Social support and survival in young women with breast carcinoma. Psycho-oncology. February 2012. 21(2):125-33. doi: 10.1002/pon.1863. Epub 2010 Oct 20.

38. Pinquart M, Duberstein PR. Associations of social networks with cancer mortality: a meta-analysis. Critical Reviews in Oncology / Hematology. August 2010. 75(2):122-37. doi: 10.1016/j.critrevonc.2009.06.003. Epub 2009 Jul 14.